A Pool Model of the Mediator Exocytosis into the Synapse
DOI:
https://doi.org/10.15407/ujpe64.9.829Keywords:
neuron, synapse, mediator, presynaptic membraneAbstract
A model describing the mediator release into a synaptic cleft and making allowance for the pool structure of the presynaptic region has been proposed. Namely, the presynaptic region is assumed to contain two pools with vesicles that accumulate the mediator. A nerve impulse stimulates the injection of mediator from the first pool into the synaptic cleft. Simultaneously, the mediator from the second pool diffuses into the first one. The replenishment of the second pool occurs by absorbing the mediator from the synaptic cleft. Various operational modes of this model are considered. In particular, specific features of the single-impulse transmission through the system are studied. The functioning of the system with a feedback (the output signal is supplied to the input of the system) is analyzed, and it is shown that, in this case, a parameter determining the feedback intensity has a critical character: at the parameter values not exceeding the critical value, the presence of feedback does not govern the functioning of the system at the qualitative level.
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