Model of Postsynaptic Membrane Deactivation

  • A. N. Vasilev Taras Shevchenko National University of Kyiv, Faculty of Physics, Chair of Theoretical Physics
  • O. V. Kulish Taras Shevchenko National University of Kyiv, Faculty of Physics, Chair of Theoretical Physics
Keywords: nerve impulse, synapse, mediator, receptor, postsynaptic membrane

Abstract

A model has been proposed to describe the deactivation of a postsynaptic membrane after its excitation by transmitting a nerve impulse across the synapse. In particular, the process of mediator release in the form of choline from the postsynaptic membrane and its diffusive excretion from the synaptic cleft are considered. The time dependence of the number of activated receptors, the dependence of the maximum number of activated receptors on the activation time, and the space-time distribution of the choline concentration in the synaptic cleft are calculated.

References

A.L. Zefirov, S.Yu. Cheranov, R.A. Giniatullin, G.F. Sitdikova, S.N. Grishin. Mediators and Synapses (KGMU, 2003) (in Russian).

A.V. Sidorov. Physiology of Intercellular Communication (BGU, 2008) (in Russian).

A.V. Chalyi, A.N. Vasilev, E.V. Zaitseva. Synaptic transmission as a cooperative phenomenon in confined systems. Cond. Matter Phys. 20, 13804 (2017). https://doi.org/10.5488/CMP.20.13804

S.O. Rizzoli, W.J. Betz. Synaptic vesicle pools. Nature Rev. Neurosci. 6, 57 (2005). https://doi.org/10.1038/nrn1583

O.M. Vasylyev, A.V. Kulish. Two-pool kinetic model of synapse activation. Zh. Fiz. Dosl. 14, 4801 (2010) (in Ukrainian).

A.N. Vasilyev, A.V. Kulish. Influence of mediator diffusion on the trigger mode of synapse operation. Biofizika 59, 373 (2014) (in Russian).

R.W. Holz, S.K.Fisher. Synaptic transmission and cellular signaling: An overview. In: Basic Neurochemistry (Elsevier, 2012), p. 235. https://doi.org/10.1016/B978-0-12-374947-5.00012-2

J. Lichtenberger, P. Fromherz. A cell-semiconductor synapse: Transistor recording of vesicle release in chromaffin cells. Biophys. J. 92, 2266 (2007). https://doi.org/10.1529/biophysj.106.096446

J. Trommershauser, R. Schneggenburger, A. Zippelius, E. Nehery. Heterogeneous presynaptic release probabilities: Functional relevance for short-term plasticity. Biophys. J. 84, 1563 (2003). https://doi.org/10.1016/S0006-3495(03)74967-4

S.I. Braichenko, O.M. Vasylyev. Modeling the postsynaptic membrane activation. Zh. Fiz. Dosl. 16, 4802 (2012).

I.C. Kleppe, H.P.C. Robinson. Determining the activation time course of synaptic AMPA receptors from openings of colocalized NMDA receptors. Biophys. J. 77, 1418 (1999). https://doi.org/10.1016/S0006-3495(99)76990-0

K. Zheng, A. Scimemi, D.A. Rusakov. Receptor actions of synaptically released glutamate: the role of transporters on the scale from nanometers to microns. Biophys. J. 95, 4584 (2008). https://doi.org/10.1529/biophysj.108.129874

A.V. Chalyi, L.M. Chernenko. Phase transition in finite-size systems and synaptic transmission. In: Dynamical Phenomena at Interfaces, Surfaces and Membranes (Nova Sci. Publ., 1993), p. 457.

A.V. Chalyi, E.V. Zaitseva. Strange attractor in kinetic model of synaptic transmission. J. Phys. Studies 11, 3, 322 (2007).

O.V. Chalyi, O.V. Zaitseva. A kinetic model of synaptic transmission on intercell interaction. Ukr. J. Phys. 54, 4, 366 (2009).

Published
2018-10-31
How to Cite
Vasilev, A., & Kulish, O. (2018). Model of Postsynaptic Membrane Deactivation. Ukrainian Journal of Physics, 63(10), 919. https://doi.org/10.15407/ujpe63.10.919
Section
Physics of liquids and liquid systems, biophysics and medical physics