Optimized Synthesis and Spectral Characterization of Some Hydrazones Based on 5-Nitroindazole with Pharmacological Potential

  • C. Cheptea “Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Medical Bioengineering
  • L. M. Ivan ”Al. I. Cuza” University, Faculty of Physics
  • D. O. Dorohoi ”Al. I. Cuza” University, Faculty of Physics
  • V. Sunel “Al. I. Cuza” University, Faculty of Chemistry
  • I. Hurjui “Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Medicine
  • C. I. Saveanu “Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Dental Medicine
  • A. I. Galaction “Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Medical Bioengineering
Keywords: Hydrazones, HyperChem, antitumor effect

Abstract

A number of new hydrazones with biological activity are synthesized on the basis of 5-nitroindazole. The most efficient conditions of their synthesis with maximum reaction yield are established. The chemical structure of new compounds is found by the elemental analysis, FTIR spectroscopy, and 1H-NMR method. The data of spectral analysis were verified by calculations with the HyperChem software. Toxicological tests indicate that the synthesized hydrazones have the antitumor effect.

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Published
2018-10-19
How to Cite
Cheptea, C., Ivan, L., Dorohoi, D., Sunel, V., Hurjui, I., Saveanu, C., & Galaction, A. (2018). Optimized Synthesis and Spectral Characterization of Some Hydrazones Based on 5-Nitroindazole with Pharmacological Potential. Ukrainian Journal of Physics, 59(3), 313. https://doi.org/10.15407/ujpe59.03.0313
Section
Solid matter