TY - JOUR AU - Malomuzh, N. P. AU - Bulavin, L. A. AU - Gotsulskyi, V. Ya. AU - Guslisty, A. A. PY - 2020/03/03 Y2 - 2024/03/29 TI - Characteristic Changes in the Density and Shear Viscosity of Human Blood Plasma with Varying Protein Concentration JF - Ukrainian Journal of Physics JA - Ukr. J. Phys. VL - 65 IS - 2 SE - Physics of liquids and liquid systems, biophysics and medical physics DO - 10.15407/ujpe65.2.151 UR - https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2019422 SP - 151 AB - <p>The density and shear viscosity of human blood plasma and their dependence on the concentration of proteins (albumin, y-globulin, fibrinogen, etc.) entering the natural blood composition have been studied. The biomaterial concentration is varied by diluting the blood plasma with the isotonic aqueous solution. It is shown that a decrease in the biomaterial concentration down to 0.91 of its initial value leads to a drastic change in the plasma density and to a change in the character of the concentration dependence of the shear viscosity of blood plasma. A hypothesis is put forward that the observed changes in the density and shear viscosity result from the structural transformations induced by oligomerization processes; first of all, by the albumin dimerization. A conclusion is drawn that the introduced blood substitutes should not exceed 10% of the blood mass; otherwise, structural transformations of a biomaterial in blood plasma can be provoked.</p> ER -