@article{Kutsevol_Naumenko_Chumachenko_Yeshchenko_Harahuts_Pavlenko_2018, title={Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin}, volume={63}, url={https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2018033}, DOI={10.15407/ujpe63.6.513}, abstractNote={<p style="-qt-block-indent: 0; text-indent: 0px; margin: 0px;">Hybrid nanosystems consisting of star-like copolymer Dextran-graft-Polyacrylamide in the anionic form (D-g-PAA(PE)), silver nanoparticles (AgNPs), and cisplatin (cis-Pt) have been synthesized in water and characterized by TEM, DLS, FTIR, and UV-Vis spectroscopies. It is shown that cis-Pt forms a complex with carboxylate groups of the polymer. For the ternary system Polymer/AgNPs/cis-Pt, a change in the hydrophilic-hydrophobic balance of a polymer molecule (due to the complexation with cis-Pt) and the aggregation of macromolecules, as well as to some agglomeration AgNPs, are revealed. The decrease of the antitumor efficiency of the hybrid ternary nanosystem Polymer/AgNPs/cis-Pt in comparison with the Polymer/cis-Pt system is discussed.</p>}, number={6}, journal={Ukrainian Journal of Physics}, author={Kutsevol, N. and Naumenko, A. and Chumachenko, V. and Yeshchenko, O. and Harahuts, Yu. and Pavlenko, V.}, year={2018}, month={Jul.}, pages={513} }