Morphology of the Micelles Formed by a Comb-Like PEG-Containing Copolymer Loaded with Antitumor Substances with Different Water Solubilities

  • N. Ye. Mitina Lviv Polytechnic National University
  • A. O. Riabtseva Lviv Polytechnic National University, Queen’s University
  • V. M. Garamus Helmholtz-Zentrum Geesthacht: Centre for Materials and Coastal Research (HZG)
  • R. B. Lesyk Danylo Halytsky Lviv National Medical University
  • K. A. Volyanyuk Lviv Polytechnic National University
  • O. M. Izhyk Lviv Polytechnic National University
  • O. S. Zaichenko Lviv Polytechnic National University
Keywords: small-angle X-ray scattering, micelle morphology, hydrophobic/hydrophilic drugs, polymer-drug complexes

Abstract

The controlled delivery of anticancer drugs is driven by their interaction with carrier molecules. By creating complicated micelle-like complexes, amphiphilic polymers provide an opportunity to load drugs of various kinds. In this work, the interaction of the comb-like PEG-containing polymer poly(VEP-co-GMA)-graft-PEG with the water-soluble antitumor antibiotic doxorubicin and new water-insoluble derivatives of thiozalidinone Les-3883 characterized by a high anticancer efficiency has been studied in aqueous solutions by means of the SAXS, DLS, TEM, and photoluminescence methods. The formation of polymer micelles and their complexes with drugs, as well as their structural changes, is observed. The obtained results give evidence that the mechanism of organization of supramolecular complexes depends on the drug solubility in water. A potential capability of poly(VEP-co-GMA)-graft-PEG to prolong the drug circulation lifetime is confirmed.

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Published
2020-07-30
How to Cite
Mitina, N., Riabtseva, A., Garamus, V., Lesyk, R., Volyanyuk, K., Izhyk, O., & Zaichenko, O. (2020). Morphology of the Micelles Formed by a Comb-Like PEG-Containing Copolymer Loaded with Antitumor Substances with Different Water Solubilities. Ukrainian Journal of Physics, 65(8), 670. https://doi.org/10.15407/ujpe65.8.670
Section
Physics of liquids and liquid systems, biophysics and medical physics