Complexation Peculiarities in “Doxorubicin–Bovine Serum Albumin–Gold Nanoparticles” Heterosystem. The Fluo-rescence Study

  • N. A. Goncharenko Taras Shevchenko National University of Kyiv, Faculty of Physics
  • O. P. Dmytrenko Taras Shevchenko National University of Kyiv, Faculty of Physics
  • O. L. Pavlenko Taras Shevchenko National University of Kyiv, Faculty of Physics
  • M. P. Kulish Taras Shevchenko National University of Kyiv, Faculty of Physics
  • I. P. Pundyk Taras Shevchenko National University of Kyiv, Faculty of Physics
  • A. I. Lesyuk Taras Shevchenko National University of Kyiv, Faculty of Physics
  • T. O. Busko Taras Shevchenko National University of Kyiv, Faculty of Physics
  • A. M. Lopatynskyy V.E. Lashkaryov Institute of Semiconductor Physics, Nat. Acad. of Sci. of Ukraine
  • V. I. Chegel V.E. Lashkaryov Institute of Semiconductor Physics, Nat. Acad. of Sci. of Ukraine
  • V. K. Lytvyn V.E. Lashkaryov Institute of Semiconductor Physics, Nat. Acad. of Sci. of Ukraine
  • M. I. Kaniuk O.V. Palladin Institute of Biochemistry, Nat. Acad. of Sci. of Ukraine
Keywords: doxorubicin, bovine serum albumin, gold nanoparticles, complexation, fluorescence, localized surface plasmon resonance

Abstract

The fluorescence (FL) quenching in aqueous solutions of doxorubicin (DOX)–bovine serum albumin (BSA)–gold nanoparticles (AuNPs) is studied. The existence of additional mechanisms of DOX-BSA complex formation leading to an increase in the binding constant K and a decrease in the number of binding sites n and the distance between the fluorophore and energy acceptors due to the presence of gold nanoparticles is shown.

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Published
2020-06-09
How to Cite
Goncharenko, N., Dmytrenko, O., Pavlenko, O., Kulish, M., Pundyk, I., Lesyuk, A., Busko, T., Lopatynskyy, A., Chegel, V., Lytvyn, V., & Kaniuk, M. (2020). Complexation Peculiarities in “Doxorubicin–Bovine Serum Albumin–Gold Nanoparticles” Heterosystem. The Fluo-rescence Study. Ukrainian Journal of Physics, 65(6), 468. https://doi.org/10.15407/ujpe65.6.468
Section
Optics, atoms and molecules