Structure and Mechanical Properties of the Polymer Base of Medical Sponges with the Addition of Methyluracil

Authors

  • I. Doroshenko Taras Shevchenko National University of Kyiv
  • A. Misiura Taras Shevchenko National University of Kyiv, E.O. Paton Electric Welding Institute of Nat. Acad. Sci. of Ukraine
  • O. Dmytrenko Taras Shevchenko National University of Kyiv
  • M. Kulish Taras Shevchenko National University of Kyiv
  • D. Kostsiukevych Taras Shevchenko National University of Kyiv
  • L. Davtian Pharmaceutical Technology and Biopharmacy department, Shupyk National Healthcare University of Ukraine
  • A. Drozdova Pharmaceutical Technology and Biopharmacy department, Shupyk National Healthcare University of Ukraine

DOI:

https://doi.org/10.15407/ujpe70.8.524

Keywords:

methyluracil, medical sponges, IR spectra, polymer, gelatin

Abstract

The interaction between the gelatin-based polymer matrix, used as the base for medical sponges, and methyluracil – a filler with wound-healing and regenerative properties – is studied. Analysis of IR absorption spectra shows that methyluracil does not interact with gelatin, indicating that gelatin can be used as a neutral base for sponges. Examination of the structure and thermomechanical properties of medical sponge samples with varying the methyluracil content, using optical microscopy and thermomechanical analysis, confirms that the addition of methyluracil does not affect the structure or mechanical properties of the gelatin polymer matrix. Thus, the compatibility of methyluracil with the gelatin-based polymer matrix of surgical sponges is demonstrated.

References

1. A. Nepal, H.D.N. Tran, N.T. Nguyen, H.T. Ta. Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis. Bioact Mater. 27, 231 (2023).

https://doi.org/10.1016/j.bioactmat.2023.04.008

2. S.P. Snizhynskyi. Study of sorption activity of experimental samples of medicinal sponges. Ukr. J. Military Medicine 5 (3), 115 (2024).

https://doi.org/10.46847/ujmm.2024.4(5)-148

3. R.U. Light, H.R. Prentice. Gelatin sponge: surgical investigation of a new matrix used in conjunction with thrombin in hemostasis. Arch Surg. 51 (2), 69 (1945).

https://doi.org/10.1001/archsurg.1945.01230040074001

4. I. Doroshenko, T. Rudenok, A. Lesiuk, A. Smal, O. Dmytrenko, L. Davtian, A. Drozdova. Peculiarities of ibuprofen interaction with polyethylene glycol polymer matrix. Fiz. Nizk. Temp. 51, 237 (2025).

https://doi.org/10.1063/10.0035405

5. A. Jumabaev, H. Hushvaktov, B. Khudaykulov, A. Absanov, M. Onuk, I. Doroshenko, L. Bulavin. Formation of hydrogen bonds and vibrational processes in dimethyl sulfoxide and its aqueous solutions: Raman spectroscopy and ab initio calculations. Ukr. J. Phys. 68 (6), 375 (2023).

https://doi.org/10.15407/ujpe68.6.375

6. I. Doroshenko, Ye. Vaskivskyi, Ye. Chernolevska. Structural transformations in solid and liquid n-butanol from FTIR spectroscopy. Mol. Cryst. Liq. Cryst. 697 (1), 11 (2020).

https://doi.org/10.1080/15421406.2020.1731098

7. Y. Mamunya, A. Misiura, M. Godzierz, S. Pusz, U. Szeluga, K. Olszowska, P.S. Wr'obel, A. Hercog, A. Kobyliukh, A. Pylypenko. Polymer composites with carbon fillers based on coal pitch and petroleum pitch cokes: Structure, electrical, thermal, and mechanical properties. Polymers 16 (6), 741 (2024).

https://doi.org/10.3390/polym16060741

8. K.J. Payne, A. Veis. Fourier transform IR spectroscopy of collagen and gelatin solutions: Deconvolution of the amide I band for conformational studies. Biopolymers, 27, 1749 (1988).

https://doi.org/10.1002/bip.360271105

9. D.M. Hashim, Y.B. Che Man, R. Norakasha, M. Shuhaimi, Y. Salmah, Z.A. Syahariza. Potential use of Fourier transform infrared spectroscopy for differentiation of bovine and porcine gelatins. Food Chemistry, 118, 856 (2010).

https://doi.org/10.1016/j.foodchem.2009.05.049

10. L. Grosmaire, J.-L. Delarbre. Vibrational spectra of 6-methyluracil, 6-methyl-2-thiouracil and their deuterated analogues. J. Mol. Struct. 1011, 42 (2012).

https://doi.org/10.1016/j.molstruc.2011.12.007

Published

2025-08-11

Issue

Section

Physics of liquids and liquid systems, biophysics and medical physics

How to Cite

Structure and Mechanical Properties of the Polymer Base of Medical Sponges with the Addition of Methyluracil. (2025). Ukrainian Journal of Physics, 70(8), 524. https://doi.org/10.15407/ujpe70.8.524

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