Aggregation Processes in Hybrid Nanosystem Polymer/Nanosilver/Cisplatin
DOI:
https://doi.org/10.15407/ujpe63.6.513Keywords:
silver nanoparticles, branched polymer, polyelectrolyte, cisplatin, aggregationAbstract
Hybrid nanosystems consisting of star-like copolymer Dextran-graft-Polyacrylamide in the anionic form (D-g-PAA(PE)), silver nanoparticles (AgNPs), and cisplatin (cis-Pt) have been synthesized in water and characterized by TEM, DLS, FTIR, and UV-Vis spectroscopies. It is shown that cis-Pt forms a complex with carboxylate groups of the polymer. For the ternary system Polymer/AgNPs/cis-Pt, a change in the hydrophilic-hydrophobic balance of a polymer molecule (due to the complexation with cis-Pt) and the aggregation of macromolecules, as well as to some agglomeration AgNPs, are revealed. The decrease of the antitumor efficiency of the hybrid ternary nanosystem Polymer/AgNPs/cis-Pt in comparison with the Polymer/cis-Pt system is discussed.
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